Oxidative Stress Exercise And Aging Pdf

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Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage.

Oxidative stress, aging, and diseases

Reactive oxygen and nitrogen species RONS are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer , including sarcopenia and frailty.

Oxidative Stress in Aging

Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 30 November Published 26 April Volume Pages — Review by Single anonymous peer review.

The aim of this study was to evaluate whether oxidative stress markers and biomarkers of muscle injury would be affected by aging at rest and in response to an incremental exhaustive exercise. Fifteen young MDA has increased only in the older group 0. CK increased in both groups young group: These findings indicate that aging is associated with a decrease in antioxidant efficiency and an increase in oxidative stress damage. Furthermore, older adults would not more susceptible to exercise-induced muscle injury than young people. This is an open-access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Oxidative Stress Across the Exercise Continuum (H M Alessio); Oxidative Stress and Antioxidant Defense: Effects of Aging and Exercise (L L Ji); Muscle, Oxidative​.


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It seems that you're in Germany. We have a dedicated site for Germany. Human aging is a complex phenomenon - not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation.

Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases.

The hormesis theory purports that biological systems respond with a bell-shaped curve to exposure to chemicals, toxins, and radiation.

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Metrics details. This study aimed to evaluate the effect of different levels of exercise on markers of oxidative stress and selected metabolic parameters in Ghanaian young adults. The study provides a first report on the risk associated with increase in oxidative stress and the importance of walking as a health promotion intervention among young Ghanaian adults. There is little doubt that physical exercise improves quality of life, reduces oxidative damage and prevents the incidence of several disorders including diabetes and cardiovascular disease [ 1 , 2 , 3 , 4 , 5 ]. Beneficial effects on the antioxidant system have also been reported [ 6 , 7 ]. There is, however a continuous debate on exercise type, intensity, frequency and duration, on the health of an individual. Furthermore, research into the influence of exercise on the antioxidant system in a socio-cultural setting like Ghana remains largely unexplored.

Skeletal muscle has the unique ability to increase the rate of oxygen usage during contraction. This has led several workers to suggest that by-products of this increased oxygen consumption, oxygen-derived free radicals, may be primarily responsible for exercise-induced damage to skeletal muscle. However, because of this rapidly changing redox state, skeletal muscle has developed a number of different endogenous mechanisms which adapt rapidly following a period of exercise. These include numerous structural and biochemical changes such as increased muscle activity of antioxidant enzymes and content of stress or heat shock proteins HSPs. This adaptation is associated with protection against the potentially damaging effects of a second period of exercise.

There is mounting evidence based on epidemiologic and experimental studies that physical activity and exercise training combat the sequels of aging. Physical activity is defined as any bodily movement coordinated by skeletal muscles, which increases energy expenditure over resting condition [ 1 ], whereas exercise training is a more regular and structured form of physical activity. Higher levels of physical activity and regular exercise are associated with reduced risks of all-cause mortality [ 2 — 20 ] and also with increased longevity [ 18 , 21 — 23 ]. In fact, the World Health Organization has identified physical inactivity as the fourth leading risk factor for global mortality [ 24 ]. Furthermore, physical activity and exercise training reduce the risk of age-associated diseases, namely, cardiovascular diseases [ 4 , 10 , 25 — 31 ], type 2 diabetes [ 32 ], metabolic syndrome [ 33 ], colon cancer [ 34 ], obesity [ 35 ], osteoporosis [ 36 ], sarcopenia [ 37 ], anxiety [ 38 ], and cognitive impairment [ 39 — 41 ].

Oxidative stress is the total burden placed on organisms by the constant production of free radicals in the normal course of metabolism plus whatever other pressures the environment brings to bear natural and artificial radiation, toxins in air, food and water; and miscellaneous sources of oxidizing activity, such as tobacco smoke. The positive health benefits stemming from physical activity are well-established. Just 30 minutes a day of moderate-intensity exercise reduces the rate of developing various non-communicable diseases including diabetes and atherosclerosis. Noteworthy is that, despite of an unclear explanation, there are epidemiological data that paradoxically imply that a very high volume of energy expenditure is related to a decrease in cardiovascular health.

Очевидно, получалась бессмыслица. Желая помочь, Беккер обратил их внимание на то, что все показанные ему иероглифы объединяет нечто общее - они одновременно являются и иероглифами кандзи. В комнате тут же стало тихо.

5 Response
  1. Mayhew D.

    Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging. March ; Oncotarget 9(24).

  2. Shawn J.

    Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms.

  3. Roland M.

    Request PDF | Oxidative stress, exercise and aging | This book brings together some of the leading researchers in the actively investigated field of oxidative.

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