Vitamin B12 Metabolism And Status During Pregnancy Lactation And Infancy Pdf

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The Spanish Association of Pediatrics has as one of its main objectives the dissemination of rigorous and updated scientific information on the different areas of pediatrics.

Cobalamin Status from Pregnancy to Early Childhood: Lessons from Global Experience

Metrics details. In infants, vitamin B12 deficiency may be due to an inborn error of absorption and metabolism, or nutritional problems. An exclusively breastfed 5-month-old Italian male infant, who was born after a normal full-term pregnancy to a vegan mother who was apparently daily treated with a multivitamin oral preparation during the second and third trimester, was hospitalised because of poor weight gain, feeding difficulties, severe pallor, muscle hypotonia and somnolence. Upon admission, his weight, length and head circumference were below the third percentile, he had an enlarged liver and spleen, and showed a significant delay in developmental milestones and communicative reactions. He had a hemoglobin level of 4. Magnetic resonance imaging of the brain showed mild dilatation of the lateral ventricles with diffuse delayed myelination.

Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin

Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores low or very low plasma cobalamin will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation from diet or supplements is transferred to the child and is not likely to correct cobalamin status in depleted women. The prevalence of low cobalamin status is high especially in low-income settings or in populations with a low intake of animal products. Folate and cobalamin play interdependent roles in one-carbon metabolism. Although folic acid supplementation during early pregnancy is widely recommended and practiced, cobalamin supplementation during pregnancy and lactation has received little attention. Furthermore, the intake recommendations for pregnant and lactating women and in early life need reevaluation in the light of newly available evidence in the field.

Author disclosures: C. Duggan, K. Srinivasan, T. Thomas, T. Samuel, R. Rajendran, S.

Vitamin B12 Metabolism and Status during Pregnancy, Lactation and Infancy. an intrinsic factor-B 12 complex which is recognized by special receptors in.

Dorothy J. VanderJagt, Innocent A. Ujah, Eugene I. Crossey, Robert H. Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants.

It is generally assumed that vitamin B 12 deficiency only occurs during pregnancy and lactation in women who have consumed no animal products for a substantial period of time. Also, there is recent evidence that vitamin B 12 deficiency may be more prevalent in women and infants in some developing countries than formerly appreciated. In view of the potential for vitamin B 12 deficiency to cause permanent neurological damage, it is important to understand the relationships between maternal intake and metabolism of vitamin B 12 during pregnancy and lactation, and their impact on the mother, fetus, neonate, and secretion of the vitamin in breast milk. Unable to display preview. Download preview PDF.

Pregnancy and Lactation

Epidemiological and experimental studies indicate that the altered fetal and neonatal environment influences physiological functions and may increase the risk of developing chronic diseases in adulthood. Because homocysteine Hcy metabolic imbalance is considered a risk factor for neurodegenerative diseases, we investigated whether maternal Vitamin B deficiency during early development alters the offspring's methionine-homocysteine metabolism in their brain. After birth, the offspring were organized into the following groups: control CT , deficient diet during pregnancy and lactation DPL and deficient diet during pregnancy DP. The mice were euthanized at various stages of development. Exposure to a Vitamin B-deficient diet during the ontogenic plasticity period had a negative impact on plasma folate and brain cortex SAM concentrations in aged DPL males. Additionally, this manipulation seemed to affect the female and male offspring differently.

Три месяца назад до Фонтейна дошли слухи о том, что от Стратмора уходит жена. Он узнал также и о том, что его заместитель просиживает на службе до глубокой ночи и может не выдержать такого напряжения. Несмотря на разногласия со Стратмором по многим вопросам, Фонтейн всегда очень высоко его ценил. Стратмор был блестящим специалистом, возможно, лучшим в агентстве. И в то же время после провала с Попрыгунчиком Стратмор испытывал колоссальный стресс.

Его редеющие седые волосы спутались, и даже несмотря на прохладу, создаваемую мощным кондиционером, на лбу у него выступили капельки пота.

В морг он не пошел, поскольку в этот момент напал на след еще какого-то парня в пиджаке и галстуке, вроде бы штатского. - Штатского? - переспросил Фонтейн. Скорее всего это игры Стратмора: он мудро решил не впутывать в это дело агентство. - Фильтры Протокола передачи файлов выходят из строя! - крикнул кто-то из технического персонала.

Беккер успел отскочить в сторону и окликнул санитара. - Dоnde esta el telefono. Не снижая скорости, мужчина указал Беккеру на двустворчатую дверь и скрылся за поворотом.

Выдержав паузу, он как бы нехотя вздохнул: - Хорошо, Грег. Ты выиграл. Чего ты от меня хочешь. Молчание.

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